Mycoplasma Superantigen Is a CDR 3 - dependent Ligand for the T Cell Antigen Receptor By Andrew
نویسندگان
چکیده
From the * Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York 10029; the ‡ Howard Hughes Medical Institute, The Rockefeller University, New York 10021; the § Howard Hughes Medical Institute, Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York 10029; and the i Immunology Program, Graduate School of Medical Sciences, and the Department of Medicine, Cornell University Medical College, New York 10021
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Mycoplasma Superantigen Is a CDR3-dependent Ligand for the T Cell Antigen Receptor
Superantigens are defined as proteins that activate a large number of T cells through interaction with the Vbeta region of the T cell antigen receptor (TCR). Here we demonstrate that the superantigen produced by Mycoplasma arthritidis (MAM), unlike six bacterial superantigens tested, interacts not only with the Vbeta region but also with the CDR3 (third complementarity-determining region) of TC...
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